Nlgn2^tm1.1Gchn
Targeted Allele Detail

Summary

• Symbol: Nlgn2^tm1.1Gchn
• Name: neuroligin 2; targeted mutation 1.1, Gong Chen
• MGI ID: MGI:6158645
• Synonyms: Nlgn2^R215H
• Gene: Nlgn2 Location: Chr11:69713949-69728610 bp, - strand Genetic Position: Chr11, 42.89 cM
• Alliance: Nlgn2^tm1.1Gchn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272181
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S/SvEv x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP site and an FRT-flanked PGK-neomycin cassette (in reverse transcriptional orientation) are placed in intron 3 along with a loxP site in intron 7 (thus flanking exons 4-7 with loxP sites). In addition, an Arg215His (R215H amino acid; G644A nucleotide) mutation is introduced to exon 4 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. The Arg215His (R215H) loss-of-function point mutation in the human gene has been identified in schizophrenia patients. (J:101977, J:272181)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlgn2 Mutation: 35 strains or lines available

References

• Original: J:272181 Jiang DY, et al., GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation. Mol Brain. 2018 Jun 1;11(1):31
• All: 2 reference(s)