Nr3c1tm1.2Jda
Targeted Allele Detail
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Symbol: |
Nr3c1tm1.2Jda |
Name: |
nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.2, Jonathan D Ashwell |
MGI ID: |
MGI:6158660 |
Synonyms: |
GR-null |
Gene: |
Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
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Alliance: |
Nr3c1tm1.2Jda page
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Germline Transmission: |
Earliest citation of germline transmission:
J:261396
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129 and C57BL/6
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intergenic deletion
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Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 3 and a second loxP site downstream of exon 3, followed by a frt-flanked neomycin resistance (neo) cassette. Flp-mediated recombination remvoed the neo cassette. Resulting parental mice with allele Nr3c1tm1.1Jda were crossed with actin-cre mice to delete exon 3. Mice were backcrossed to breeding out the cre transgene.
(J:261396)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nr3c1 Mutation: |
35 strains or lines available
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Original: |
J:261396 Bauerle KT, et al., Glucocorticoid Receptor Signaling Is Not Required for In Vivo Adipogenesis. Endocrinology. 2018 May 1;159(5):2050-2061 |
All: |
1 reference(s) |
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