Gt(ROSA)26Sor^{tm1(CAG-Slc39a14*L438R)Wvh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Slc39a14*L438R)Wvh}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Wim Van Hul
• MGI ID: MGI:6159129
• Synonyms: Zip14^flox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Slc39a14*L438R)Wvh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261326
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Slc39a14*L438R)Wvh} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Slc39a14 (MGI:2384851)

• Mutation details: The targeting construct inserted into the locus a CAG promoter, loxP-flanked transcriptional STOP cassette, and a mutant mouse Slc39A14 with a T to G mutation at position 1535 resulting in a lucine to arginine substitution at amino acid 438 (L438R). Cre-mediated recombination is necessary to remove the STOP cassette and get expression of the mutant protein. (J:261326)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:261326 Hendrickx G, et al., Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis. PLoS Genet. 2018 Apr;14(4):e1007321
• All: 1 reference(s)