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Fam210atm1c(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: Fam210atm1c(EUCOMM)Wtsi
Name: family with sequence similarity 210, member A; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6159130
Synonyms: Fam210aflox
Gene: Fam210a  Location: Chr18:68393258-68433404 bp, - strand  Genetic Position: Chr18, 40.98 cM
Alliance: Fam210atm1c(EUCOMM)Wtsi page
IMPC: Fam210a gene page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:261817
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 68408552 of Chromosome 18 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 68409834. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:261817)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fam210a Mutation:  17 strains or lines available
References
Original:  J:261817 Tanaka KI, et al., FAM210A is a novel determinant of bone and muscle structure and strength. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3759-E3768
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory