Klf9^tm1.1Sahay
Targeted Allele Detail

Summary

• Symbol: Klf9^tm1.1Sahay
• Name: Kruppel-like transcription factor 9; targeted mutation 1.1, Amar Sahay
• MGI ID: MGI:6159156
• Synonyms: tetO-Klf9, TRE-Klf9
• Gene: Klf9 Location: Chr19:23118590-23145493 bp, + strand Genetic Position: Chr19, 17.9 cM, cytoband C1
• Alliance: Klf9^tm1.1Sahay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261716
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A loxP site, FRT flanked pgk-neo construct, tetO construct and loxP site were inserted upstream of the translation initiation start site via homologous recombination. Flp mediated recombination removed the neo cassette. (J:261716)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klf9 Mutation: 123 strains or lines available

References

• Original: J:261716 McAvoy KM, et al., Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits. Neuron. 2016 Sep 21;91(6):1356-1373
• All: 3 reference(s)