Nipal4^tm1Akih
Targeted Allele Detail

Summary

• Symbol: Nipal4^tm1Akih
• Name: NIPA-like domain containing 4; targeted mutation 1, Akio Kihara
• MGI ID: MGI:6159563
• Synonyms: Nipal4^-
• Gene: Nipal4 Location: Chr11:46038982-46057186 bp, - strand Genetic Position: Chr11, 27.59 cM
• Alliance: Nipal4^tm1Akih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261184
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was replaced with an FRT-flanked neomycin resistance cassette. RT-PCR analysis confirmed absence of mRNA expression in the epidermis of homozygous mutant mice. (J:261184)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nipal4 Mutation: 26 strains or lines available

References

• Original: J:261184 Honda Y, et al., Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice. J Invest Dermatol. 2018 Apr;138(4):741-749
• All: 1 reference(s)