Bscl2^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Bscl2^{tm1c(EUCOMM)Hmgu}
• Name: BSCL2 lipid droplet biogenesis associated, seipin; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6159699
• Synonyms: B2^fl, Bscl2^fl
• Gene: Bscl2 Location: Chr19:8814831-8826047 bp, + strand Genetic Position: Chr19, 5.76 cM
• Alliance: Bscl2^{tm1c(EUCOMM)Hmgu} page
• IMPC: Bscl2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260853
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Flp-mediated excision of the parental Bscl2^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of lacZ reporter sequence and the neomycin selection cassette, leaving exon 5-7 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:260853)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bscl2 Mutation: 36 strains or lines available

References

• Original: J:260853 Mcilroy GD, et al., Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease. Mol Metab. 2018 Apr;10:55-65
• All: 5 reference(s)