Vmn2r1^tm2Mom
Targeted Allele Detail

Summary

• Symbol: Vmn2r1^tm2Mom
• Name: vomeronasal 2, receptor 1; targeted mutation 2, Peter Mombaerts
• MGI ID: MGI:6159872
• Synonyms: DeltaC1-GFP
• Gene: Vmn2r1 Location: Chr3:63988968-64016905 bp, + strand Genetic Position: Chr3, 30.11 cM
• Alliance: Vmn2r1^tm2Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262032
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 230 bp including exon 1 were replaced with a tau-GFP-pA cassette and self-excising ACNF neo selectable marker cassette, resulting in a null allele with GFP reporter. Immunohistochemistry of homozygotes with an antibody recognizing an epitope encoded by exons 3 and 4 failed to detect staining in the vomeronasal organ, proving this a null allele. (J:262032)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vmn2r1 Mutation: 53 strains or lines available

References

• Original: J:262032 Akiyoshi S, et al., Subpopulations of vomeronasal sensory neurons with coordinated coexpression of type 2 vomeronasal receptor genes are differentially dependent on Vmn2r1. Eur J Neurosci. 2018 Apr;47(7):887-900
• All: 1 reference(s)