Pnldc1^em2Nkn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pnldc1^em2Nkn
• Name: poly(A)-specific ribonuclease (PARN)-like domain containing 1; endonuclease-mediated mutation 2, Toru Nakano
• MGI ID: MGI:6159928
• Gene: Pnldc1 Location: Chr17:13107616-13129117 bp, - strand Genetic Position: Chr17, 8.71 cM
• Alliance: Pnldc1^em2Nkn page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 7 was targeted by an sgRNA with the CRISPR/Cas9 system, resulting in an 836 bp insertion of a retrotransposon that replaces 12 bp of exon 7. The insertion interrupts the reading frame, creating a null allele. (J:262084)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pnldc1 Mutation: 28 strains or lines available

References

• Original: J:262084 Nishimura T, et al., PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development. EMBO Rep. 2018 Mar;19(3)
• All: 1 reference(s)