Mitf^{mi-enu22(398)}
Chemically induced Allele Detail

Summary

• Symbol: Mitf^{mi-enu22(398)}
• Name: melanogenesis associated transcription factor; microphthalmia enu 22(398)
• MGI ID: MGI:6162028
• Gene: Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
• Alliance: Mitf^{mi-enu22(398)} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: This mutation was induced by treatment with ethylnitrosourea as part of a genetic screen performed at the Novartis Institute for Functional Genomics. Sequence analysis shows that the mutation is a C-to-T change at nucleotide position 205 of the cDNA, which introduces a stop codon in exon 2A, changing glutamine at position 26 of the MITF protein to STOP. (J:154486)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mitf Mutation: 74 strains or lines available

References

• Original: J:154486 Bauer GL, et al., The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue. Genetics. 2009 Oct;183(2):581-94
• All: 3 reference(s)