St7^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: St7^em1(IMPC)J
• Name: suppression of tumorigenicity 7; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6162622
• Gene: St7 Location: Chr6:17693579-17943022 bp, + strand Genetic Position: Chr6, 8.0 cM, cytoband A2
• Alliance: St7^em1(IMPC)J page
• IMPC: St7 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CCATTTTAACTAAATAATAT and AGTATCACGCATGCATCCCA, which resulted in a 467 bp deletion beginning at Chromosome 6 position 17,834,456 bp and ending after 17,834,922 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001300931 (exon 3) and 307 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 35 and early truncation 8 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any St7 Mutation: 56 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)