Kdm5c^tm1.2Yshi
Targeted Allele Detail

Summary

• Symbol: Kdm5c^tm1.2Yshi
• Name: lysine demethylase 5C; targeted mutation 1.2, Yang Shi
• MGI ID: MGI:6163735
• Gene: Kdm5c Location: ChrX:151016016-151057531 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband F2-F4
• Alliance: Kdm5c^tm1.2Yshi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262206
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 11 and a FRT-flanked PGK-neomycin resistance cassette and a second loxP site were inserted downstream of exon 12. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination deleted exons 11 and 12. Western blot analysis confirmed absence of protein in hemizygous males. (J:262206)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm5c Mutation: 23 strains or lines available

References

• Original: J:262206 Iwase S, et al., A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation. Cell Rep. 2016 Feb 9;14(5):1000-1009
• All: 5 reference(s)