Nfatc1^{em4(cre/ERT2)Bzsh}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nfatc1^{em4(cre/ERT2)Bzsh}
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; endonuclease-mediated mutation 4, Bin Zhou
• MGI ID: MGI:6163791
• Synonyms: Nfatc1-2A-CreER
• Gene: Nfatc1 Location: Chr18:80649420-80756286 bp, - strand Genetic Position: Chr18, 53.66 cM, cytoband E4
• Alliance: Nfatc1^{em4(cre/ERT2)Bzsh} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Nfatc1^{em4(cre/ERT2)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nfatc1 (MGI:102469)

• Mutation details: The line was generated by inserting a cDNA encoding Cre recombinase fused with a mutant form of estrogen receptor hormon-binding domaine C (ERT2) followed by an 2A peptide sequence into the 9th exon using the CRISPR/Cas9 technology. (J:262529)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nfatc1 (mouse) Summary of all recombinase alleles driven by Nfatc1. Comparative matrix view of recombinase activities Alliance mouse Nfatc1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfatc1 Mutation: 49 strains or lines available

References

• Original: J:262529 Zhang H, et al., Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Res. 2017 Sep;27(9):1157-1177
• All: 2 reference(s)