Npffr2^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Npffr2^tm1.2Ics
• Name: neuropeptide FF receptor 2; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:6163806
• Gene: Npffr2 Location: Chr5:89675288-89731599 bp, + strand Genetic Position: Chr5, 44.32 cM
• Alliance: Npffr2^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245025
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was flanked by loxP sites and a FRT-flanked neomycin selection cassette was inserted downstream of the second loxP site. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination deleted exon 4. Absence of protein was confirmed by receptor binding assay. (J:245025)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npffr2 Mutation: 26 strains or lines available

References

• Original: J:245025 Waqas SFH, et al., Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. J Clin Invest. 2017 Jun 30;127(7):2842-2854
• All: 1 reference(s)