Mkrn2^tm1.1Bhj
Targeted Allele Detail

Summary

• Symbol: Mkrn2^tm1.1Bhj
• Name: makorin, ring finger protein, 2; targeted mutation 1.1, Bing-Hua Jiang
• MGI ID: MGI:6163817
• Gene: Mkrn2 Location: Chr6:115578844-115598647 bp, + strand Genetic Position: Chr6, 53.61 cM
• Alliance: Mkrn2^tm1.1Bhj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250191
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites that flanked exons 2-6 were recombined via cre-mediated recombination, deleting these exons in the germline. Immnuoblotting analysis using testis extracts verified the absence of the encoded protein protein in homozygous mice. (J:250191)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mkrn2 Mutation: 24 strains or lines available

References

• Original: J:250191 Qian X, et al., Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility. Sci Rep. 2016 Dec 23;6:39318
• All: 3 reference(s)