Adamts9^tm1.2Cvrk
Targeted Allele Detail

Summary

• Symbol: Adamts9^tm1.2Cvrk
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 9; targeted mutation 1.2, Catherine D Van Raamsdonk
• MGI ID: MGI:6163820
• Gene: Adamts9 Location: Chr6:92749680-92920473 bp, - strand Genetic Position: Chr6, 41.41 cM
• Alliance: Adamts9^tm1.2Cvrk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262498
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4, 5, and 6 are flanked by LoxP sites. The deletion of these exons is expected to remove amino acids 227 to 390, which includes part of the peptidase M12B domain. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. Cre-mediated recombination removed exons 4 through 6. (J:262498)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts9 Mutation: 90 strains or lines available

References

• Original: J:262498 Tharmarajah G, et al., Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase. Pigment Cell Melanoma Res. 2018 May 21
• All: 1 reference(s)