Rnf128^tm1.2Cmse
Targeted Allele Detail

Summary

• Symbol: Rnf128^tm1.2Cmse
• Name: ring finger protein 128; targeted mutation 1.2, Christine M Seroogy
• MGI ID: MGI:6164139
• Gene: Rnf128 Location: ChrX:138464089-138573894 bp, + strand Genetic Position: ChrX, 61.35 cM
• Alliance: Rnf128^tm1.2Cmse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245025
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites and a FRT-flanked PGK-neomycin cassette was inserted downstream of the floxed exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination deleted exon 2. Deletion of exon 2 (bp 485-732) results in a premature stop codon at amino acid 168. (J:245025)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf128 Mutation: 10 strains or lines available

References

• Original: J:245025 Waqas SFH, et al., Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. J Clin Invest. 2017 Jun 30;127(7):2842-2854
• All: 1 reference(s)