Trim8^tm1Hbsh
Targeted Allele Detail

Summary

• Symbol: Trim8^tm1Hbsh
• Name: tripartite motif-containing 8; targeted mutation 1, H-B Shu
• MGI ID: MGI:6164179
• Synonyms: Trim8^-
• Gene: Trim8 Location: Chr19:46490087-46504894 bp, + strand Genetic Position: Chr19, 38.92 cM, cytoband D1
• Alliance: Trim8^tm1Hbsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251270
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first exon of the gene was replaced with a loxP-flanked neomycin cassette, resulting in a frame-shift mutation. Immunoblot analysis of protein extracts derived from mutant embryonic fibroblasts showed no detectable protein expression from this allele. (J:251270)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim8 Mutation: 28 strains or lines available

References

• Original: J:251270 Ye W, et al., TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction. J Immunol. 2017 Sep 1;199(5):1856-1864
• All: 1 reference(s)