Card14^em9Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Card14^em9Lutzy
• Name: caspase recruitment domain family, member 14; endonuclease-mediated mutation 9, Cathy Lutz
• MGI ID: MGI:6164625
• Synonyms: Card14deltaE138
• Gene: Card14 Location: Chr11:119198594-119236201 bp, + strand Genetic Position: Chr11, 83.36 cM
• Alliance: Card14^em9Lutzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 endonuclease mediated genome editing was used to introduce a deletion of a GAG codon from exon 6 that results in the deletion of the glutamic acid (E) at position 138. Card14^em5Lutzy and Card14^em9Lutzy were generated from two different founders, both carry the same mutation. (J:262723)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Card14 Mutation: 40 strains or lines available

References

• Original: J:262723 Mellett M, et al., CARD14 gain-of-function mutation alone is sufficient to drive IL-23/IL-17-mediated psoriasiform skin inflammation in vivo. J Invest Dermatol. 2018 Apr 21
• All: 3 reference(s)