Clcnkb^em1Haca
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clcnkb^em1Haca
• Name: chloride channel, voltage-sensitive Kb; endonuclease-mediated mutation 1, Hayo Castrop
• MGI ID: MGI:6164702
• Synonyms: ClC-K2^-
• Gene: Clcnkb Location: Chr4:141131664-141143325 bp, - strand Genetic Position: Chr4, 74.02 cM, cytoband E1
• Alliance: Clcnkb^em1Haca page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-mediated mutagenesis resulted in an 11 bp deletion in exon 2, near the ATG initiation codon. The deletion resulted in a frame-shift and the introduction of a premature stop codon. (J:259681)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcnkb Mutation: 27 strains or lines available

References

• Original: J:259681 Grill A, et al., Salt-losing nephropathy in mice with a null mutation of the Clcnk2 gene. Acta Physiol (Oxf). 2016 Nov;218(3):198-211
• All: 1 reference(s)