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Lag3tm1Daav
Targeted Allele Detail
Summary
Symbol: Lag3tm1Daav
Name: lymphocyte-activation gene 3; targeted mutation 1, Dario AA Vignali
MGI ID: MGI:6188309
Synonyms: Lag3L-YFP
Gene: Lag3  Location: Chr6:124881324-124888668 bp, - strand  Genetic Position: Chr6, 59.17 cM
Alliance: Lag3tm1Daav page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:260063
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, Reporter)
Mutation:    Insertion
 
Mutation detailsExon 7, containing the CP cleavage site, was flanked by loxP sites. An IRES-YFP was inserted between the Lag3 stop codon and the pA. A FRT-flanked neomycin selection cassette was inserted just past the pA. Upon cre-mediated removal of exon 7, these mice are expected to lack cell surface expression of LAG3 and thus cannot mediate signaling but continue to release soluble protein. (J:260063)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lag3 Mutation:  43 strains or lines available
References
Original:  J:260063 Zhang Q, et al., LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes. Sci Immunol. 2017 Mar 31;2(9)
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory