Lag3tm1Daav
Targeted Allele Detail
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Symbol: |
Lag3tm1Daav |
Name: |
lymphocyte-activation gene 3; targeted mutation 1, Dario AA Vignali |
MGI ID: |
MGI:6188309 |
Synonyms: |
Lag3L-YFP |
Gene: |
Lag3 Location: Chr6:124881324-124888668 bp, - strand Genetic Position: Chr6, 59.17 cM
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Alliance: |
Lag3tm1Daav page
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Germline Transmission: |
Earliest citation of germline transmission:
J:260063
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, Reporter) |
Mutation: |
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Insertion
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Mutation details: Exon 7, containing the CP cleavage site, was flanked by loxP sites. An IRES-YFP was inserted between the Lag3 stop codon and the pA. A FRT-flanked neomycin selection cassette was inserted just past the pA. Upon cre-mediated removal of exon 7, these mice are expected to lack cell surface expression of LAG3 and thus cannot mediate signaling but continue to release soluble protein.
(J:260063)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lag3 Mutation: |
43 strains or lines available
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Original: |
J:260063 Zhang Q, et al., LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes. Sci Immunol. 2017 Mar 31;2(9) |
All: |
3 reference(s) |
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