Atp11atm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Atp11atm1c(KOMP)Wtsi |
Name: |
ATPase, class VI, type 11A; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6188633 |
Synonyms: |
Atp11atm1c |
Gene: |
Atp11a Location: Chr8:12807016-12918728 bp, + strand Genetic Position: Chr8, 5.73 cM, cytoband A2
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Alliance: |
Atp11atm1c(KOMP)Wtsi page
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IMPC: |
Atp11a gene page |
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Mutant Cell Line: |
EPD0111_4_B04 |
Germline Transmission: |
Earliest citation of germline transmission:
J:262981
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Parent Cell Line: |
JM8.F6 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 12872185 of Chromosome 8 upstream of the critical exons 7 and 8 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 7 and 8 at position 12873331. The critical exons 7 and 8 are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:262981)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Atp11a Mutation: |
54 strains or lines available
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Original: |
J:262981 Tsuchiya M, et al., Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nat Commun. 2018 May 24;9(1):2049 |
All: |
4 reference(s) |
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