Svep1^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Svep1^{tm1c(EUCOMM)Hmgu}
• Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6188643
• Synonyms: Polydom^fl, Svep1^delta, Svep1^flox
• Gene: Svep1 Location: Chr4:58042796-58206596 bp, - strand Genetic Position: Chr4, 31.87 cM, cytoband B-C2
• Alliance: Svep1^{tm1c(EUCOMM)Hmgu} page
• IMPC: Svep1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262023
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 58133064 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 58133064. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase mediated excission of the lacZ and neo cassettes. (J:262023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Svep1 Mutation: 169 strains or lines available

References

• Original: J:262023 Morooka N, et al., Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circ Res. 2017 Apr 14;120(8):1276-1288
• All: 4 reference(s)