Itsn2^tm1Kure
Targeted Allele Detail

Summary

• Symbol: Itsn2^tm1Kure
• Name: intersectin 2; targeted mutation 1, Shigeo Kure
• MGI ID: MGI:6188888
• Synonyms: Itsn2^L-
• Gene: Itsn2 Location: Chr12:4642792-4763952 bp, + strand Genetic Position: Chr12, 2.09 cM, cytoband A1.1
• Alliance: Itsn2^tm1Kure page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262845
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: Exon 31 was replaced with a modified exon containing an SV40 polyadenylation sequence and a recombinase recognition site flanked neomycin resistance cassette. This allele does not produce the long isoform. (J:262845)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itsn2 Mutation: 91 strains or lines available

References

• Original: J:262845 Ashraf S, et al., Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment. Nat Commun. 2018 May 17;9(1):1960
• All: 1 reference(s)