H2-Ob^em1Tvg
Endonuclease-mediated Allele Detail

Summary

• Symbol: H2-Ob^em1Tvg
• Name: histocompatibility 2, O region beta locus; endonuclease-mediated mutation 1, Tatyana Golovkina
• MGI ID: MGI:6189528
• Synonyms: Line 134
• Gene: H2-Ob Location: Chr17:34457879-34464882 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ob^em1Tvg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This CRISPR/Cas9 mediated mutation has a 52 bp deletion from Chromosome 17 34,242,620 bp through 34,242,672 bp (GRCm38) and a 9 bp insertion, ATGGACCTT, at the site of this deletion. (J:254532)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-Ob Mutation: 24 strains or lines available

References

• Original: J:254532 Denzin LK, et al., Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob. Immunity. 2017 Aug 15;47(2):310-322.e7
• All: 4 reference(s)