Sephs1^tm1.2Dhat
Targeted Allele Detail

Summary

• Symbol: Sephs1^tm1.2Dhat
• Name: selenophosphate synthetase 1; targeted mutation 1.2, Dolph L Hatfield
• MGI ID: MGI:6189534
• Gene: Sephs1 Location: Chr2:4886375-4915368 bp, + strand Genetic Position: Chr2, 3.02 cM
• Alliance: Sephs1^tm1.2Dhat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245139
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. (J:245139)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sephs1 Mutation: 37 strains or lines available

References

• Original: J:245139 Tobe R, et al., Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals. Biochem J. 2016 Jul 15;473(14):2141-54
• All: 3 reference(s)