Lrrtm3^tm1Msa
Targeted Allele Detail

Summary

• Symbol: Lrrtm3^tm1Msa
• Name: leucine rich repeat transmembrane neuronal 3; targeted mutation 1, Matti S Airaksinen
• MGI ID: MGI:6191636
• Gene: Lrrtm3 Location: Chr10:63764276-63926034 bp, - strand Genetic Position: Chr10, 32.57 cM
• Alliance: Lrrtm3^tm1Msa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262456
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and exon 2 were replaecd with an IRES-tauGFP-LNL cassette. Western blot analysis on crude brain extracts showed that no detectable encoded protein was present in homozygous mice. (J:262456)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrtm3 Mutation: 31 strains or lines available

References

• Original: J:262456 Laakso T, et al., LRRTM3 is dispensable for amyloid-beta production in mice. J Alzheimers Dis. 2012;31(4):759-64
• All: 3 reference(s)