Mtln^em1Rlbd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mtln^em1Rlbd
• Name: mitoregulin; endonuclease-mediated mutation 1, Ryan L Boudreau
• MGI ID: MGI:6191656
• Gene: Mtln Location: Chr2:127633308-127634408 bp, - strand Genetic Position: Chr2, 62.1 cM
• Alliance: Mtln^em1Rlbd page

Mutation origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• CRISPR-targeting removed the coding sequence. (J:263464)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Mtln^em1Rlbd/Mtln^em1Rlbd	involves: C57BL/6J * SJL/J

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cardiovascular system	√
abnormal cardiac muscle tissue morphology	√
cellular	√
abnormal oxidative phosphorylation	√
decreased fatty acid beta-oxidation	√
homeostasis/metabolism	√
decreased fatty acid beta-oxidation	√
muscle	√
abnormal cardiac muscle tissue morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtln Mutation: 6 strains or lines available

References

• Original: J:263464 Stein CS, et al., Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. Cell Rep. 2018 Jun 26;23(13):3710-3720.e8
• All: 1 reference(s)