Tssk4^tm1.1Lgyu
Targeted Allele Detail

Summary

• Symbol: Tssk4^tm1.1Lgyu
• Name: testis-specific serine kinase 4; targeted mutation 1.1, Long Yu
• MGI ID: MGI:6191661
• Gene: Tssk4 Location: Chr14:55887641-55889996 bp, + strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Tssk4^tm1.1Lgyu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263443
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the selection cassette and exon 1. Immunohistochemistry confirmed the absence of protein expression in testes. (J:263443)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tssk4 Mutation: 19 strains or lines available

References

• Original: J:263443 Wang X, et al., Tssk4 is essential for maintaining the structural integrity of sperm flagellum. Mol Hum Reprod. 2015 Feb;21(2):136-45
• All: 1 reference(s)