Dlgap2^tm1.1Ssfg
Targeted Allele Detail

Summary

• Symbol: Dlgap2^tm1.1Ssfg
• Name: DLG associated protein 2; targeted mutation 1.1, Susan Shur-Fen Gau
• MGI ID: MGI:6191669
• Gene: Dlgap2 Location: Chr8:14145865-14897680 bp, + strand Genetic Position: Chr8, 6.51 cM
• Alliance: Dlgap2^tm1.1Ssfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263415
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. Cre-mediated recombination removed exon 6 and the selection cassette. Western blot analysis confirmed the absence of protein expression in brain lysates. (J:263415)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlgap2 Mutation: 53 strains or lines available

References

• Original: J:263415 Jiang-Xie LF, et al., Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits. Mol Autism. 2014;5:32
• All: 1 reference(s)