Tg(Myh6-Mir30c-1)AEec
Transgene Detail

Summary

• Symbol: Tg(Myh6-Mir30c-1)AEec
• Name: transgene insertion A, Esther E Creemers
• MGI ID: MGI:6192033
• Transgene: Tg(Myh6-Mir30c-1)AEec Location: unknown
• Alliance: Tg(Myh6-Mir30c-1)AEec page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Mir30c-1)AEec expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir30c-1 (MGI:2676909)

• Mutation details: The murine pre-miRNA-30c-1 is under the control of the murine alpha-myosin heavy chain promoter. Northern blot analysis shows an increase in pre- and mature miRNA-30c levels, with qPCR indicating an approximate 6-fold overexpression in left ventricular tissue. Two lines were generated, A and B. This is the lower expressing line. (J:216095)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:216095 Wijnen WJ, et al., Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy. PLoS One. 2014;9(5):e96290
• All: 1 reference(s)