Hapln4^tm1Ooh
Targeted Allele Detail

Summary

• Symbol: Hapln4^tm1Ooh
• Name: hyaluronan and proteoglycan link protein 4; targeted mutation 1, Toshitaka Oohashi
• MGI ID: MGI:6192343
• Synonyms: Bral2^-
• Gene: Hapln4 Location: Chr8:70536179-70543512 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Hapln4^tm1Ooh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263658
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into exon 3 an IRES sequence, taulacZ reporter fusion gene and floxed neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:263658)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hapln4 Mutation: 19 strains or lines available

References

• Original: J:263658 Bekku Y, et al., Bral2 is indispensable for the proper localization of brevican and the structural integrity of the perineuronal net in the brainstem and cerebellum. J Comp Neurol. 2012 Jun 1;520(8):1721-36
• All: 6 reference(s)