Kdm6a^tm1Cdcn
Targeted Allele Detail

Summary

• Symbol: Kdm6a^tm1Cdcn
• Name: lysine (K)-specific demethylase 6A; targeted mutation 1, Charlie Degui Chen
• MGI ID: MGI:6192374
• Synonyms: Utx^f
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^tm1Cdcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263565
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 11 to 14 were flanked by loxP sites and a FRT-flanked PGK-neo cassette was inserted after exon 14 before the second loxP site. (J:263565)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Kdm6a^tm1Cdcn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 40 strains or lines available

References

• Original: J:263565 Zheng L, et al., Utx loss causes myeloid transformation. Leukemia. 2018 Jun;32(6):1458-1465
• All: 3 reference(s)