Tg(Erbb2*)#Maed
Transgene Detail

Summary

• Symbol: Tg(Erbb2*)#Maed
• Name: transgene insertion, Shin Maeda
• MGI ID: MGI:6192630
• Synonyms: LSL-HER2^NT
• Transgene: Tg(Erbb2*)#Maed Location: unknown
• Alliance: Tg(Erbb2*)#Maed page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Erbb2*)#Maed expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

  expresses an activated form

• Mutation details: This transgene consists of a lox-stop-lox cassette and a mutant form of activated rat Erbb2. Constitutive expression occurs following deletion of the stop element via cre-mediated recombination. (J:262746)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Erbb2*)#Maed

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:262746 Shibata W, et al., Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice. Sci Rep. 2018 Apr 18;8(1):6150
• All: 1 reference(s)