Aif1^{tm1(icre)Mabe}
Targeted Allele Detail

Summary

• Symbol: Aif1^{tm1(icre)Mabe}
• Name: allograft inflammatory factor 1; targeted mutation 1, Manabu Abe
• MGI ID: MGI:6193625
• Synonyms: Iba1-iCre
• Gene: Aif1 Location: Chr17:35389967-35394977 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Aif1^{tm1(icre)Mabe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263738
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Aif1^{tm1(icre)Mabe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aif1 (MGI:1343098)

• Mutation details: A vector was constructed to insert an improved cre recombinase, IRES, EGFP and an Frt-flanked neomycin cassette into the translation initiation site (in-frame) of the Aif1 gene by homologous recombination in RENKA ES cells. (J:263738)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aif1 (mouse) Summary of all recombinase alleles driven by Aif1. Comparative matrix view of recombinase activities Alliance mouse Aif1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aif1 Mutation: 37 strains or lines available

References

• Original: J:263738 Nakayama H, et al., Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum. Nat Commun. 2018 Jul 19;9(1):2830
• All: 1 reference(s)