Tg(Myh6-ADRB1)4Mjlo
Transgene Detail

Summary

• Symbol: Tg(Myh6-ADRB1)4Mjlo
• Name: transgene insertion 4, Martin J Lohse
• MGI ID: MGI:6193703
• Synonyms: Beta1TG4
• Transgene: Tg(Myh6-ADRB1)4Mjlo Location: unknown
• Alliance: Tg(Myh6-ADRB1)4Mjlo page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-ADRB1)4Mjlo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ADRB1 (153)

  Adrb1

  (MGI:87937)

• Mutation details: The murine alpha-myosin heavy chain promoter drives the expression of the human beta1-adrenergic receptor cDNA in adult atria and ventricles. Expression was verified in binding experiments which show a 15-fold increase in receptor numbers. (J:55719)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:55719 Engelhardt S, et al., Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7059-64
• All: 2 reference(s)