Lsm3^em1Caox
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lsm3^em1Caox
• Name: LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated; endonuclease-mediated mutation 1, Xuetao Cao
• MGI ID: MGI:6194617
• Synonyms: lnc-Lsm3b^-
• Gene: Lsm3 Location: Chr6:91493017-91499602 bp, + strand Genetic Position: Chr6, 40.58 cM, cytoband D2
• Alliance: Lsm3^em1Caox page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting removed intron 2. This allele produces variant 1 (lnc-Lsm3a) but not variant 2 (lnc-Lsm3b). (J:262834)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lsm3 Mutation: 15 strains or lines available

References

• Original: J:262834 Jiang M, et al., Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response. Cell. 2018 May 3;173(4):906-919.e13
• All: 1 reference(s)