Ythdc1^tm1.1Jw
Targeted Allele Detail

Summary

• Symbol: Ythdc1^tm1.1Jw
• Name: YTH domain containing 1; targeted mutation 1.1, Jeremy Wang
• MGI ID: MGI:6194732
• Synonyms: Ythdc1^fl
• Gene: Ythdc1 Location: Chr5:86952080-86984518 bp, + strand Genetic Position: Chr5, 43.56 cM
• Alliance: Ythdc1^tm1.1Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262823
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed hygromycin resistance cassette was inserted into intron 4 and an additional loxP site was inserted into intron 9. Cre-mediated recombination removed the selection cassette and left exons 5 through 9 floxed. (J:262823)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ythdc1 Mutation: 51 strains or lines available

References

• Original: J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412
• All: 2 reference(s)