Adam18^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Adam18^tm1Osb
• Name: a disintegrin and metallopeptidase domain 18; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6194894
• Gene: Adam18 Location: Chr8:25092262-25164771 bp, - strand Genetic Position: Chr8, 12.82 cM, cytoband A3
• Alliance: Adam18^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234235
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 4 was replaced with an FRT and loxP flanked neo cassette in inverse orientation. (J:234235)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adam18 Mutation: 75 strains or lines available

References

• Original: J:234235 Miyata H, et al., Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7704-10
• All: 1 reference(s)