Pml^tm1.1Ews
Targeted Allele Detail

Summary

• Symbol: Pml^tm1.1Ews
• Name: promyelocytic leukemia; targeted mutation 1.1, Eva W Stratford
• MGI ID: MGI:6195046
• Synonyms: Pml^C62A/C65A
• Gene: Pml Location: Chr9:58125359-58157069 bp, - strand Genetic Position: Chr9, 31.63 cM
• Alliance: Pml^tm1.1Ews page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262172
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Two zinc-binding cysteine residues were substituted for two alanine residues located in the RING domain at positions 62 and 65 (C62A and C65A). A floxed neomycin resistance cassette was removed via cre-mediated recombination. (J:262172)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pml Mutation: 92 strains or lines available

References

• Original: J:262172 Voisset E, et al., Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice. Blood. 2018 Feb 8;131(6):636-648
• All: 2 reference(s)