Ifitm5^tm1Pmof
Targeted Allele Detail

Summary

• Symbol: Ifitm5^tm1Pmof
• Name: interferon induced transmembrane protein 5; targeted mutation 1, Pierre Moffatt
• MGI ID: MGI:6195208
• Gene: Ifitm5 Location: Chr7:140528871-140530156 bp, - strand Genetic Position: Chr7, 86.17 cM
• Alliance: Ifitm5^tm1Pmof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264160
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The two coding exons were replaced by the nuclear localization signal (NLS)-tagged lacZ and PGK-Neo cassettes. RT-qPCR and Western blot analysis confirmed absence of transcript in the humerus and absence of protein in the humerus and calvaria. (J:264160)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifitm5 Mutation: 8 strains or lines available

References

• Original: J:264160 Patoine A, et al., The osteogenic cell surface marker BRIL/IFITM5 is dispensable for bone development and homeostasis in mice. PLoS One. 2017;12(9):e0184568
• All: 2 reference(s)