Cebpb^tm1.1Elgaz
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm1.1Elgaz
• Name: CCAAT/enhancer binding protein beta; targeted mutation 1.1, Mohamed Elgazzar
• MGI ID: MGI:6195224
• Synonyms: Cebpb^flox
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm1.1Elgaz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247885
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains a loxP site flanked PGK-Neo selection cassette inserted 228 bp downstream of the Cebpb polyadenylation site, and another loxP site inserted 227 bp upstream of the Cebpb initiation start site. Cre-mediated recombination removed the floxed neo cassette. (J:247885)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 26 strains or lines available

Notes

ES cell line = PRX-BALB/cJ 9

References

• Original: J:247885 McPeak MB, et al., Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice. J Leukoc Biol. 2017 Aug;102(2):191-200
• All: 2 reference(s)