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Tnfrsf1btm1.2Gkl
Targeted Allele Detail
Summary
Symbol: Tnfrsf1btm1.2Gkl
Name: tumor necrosis factor receptor superfamily, member 1b; targeted mutation 1.2, George Kollias
MGI ID: MGI:6195556
Synonyms: Tnfrsf1bD
Gene: Tnfrsf1b  Location: Chr4:144940033-144973440 bp, - strand  Genetic Position: Chr4, 78.17 cM
Alliance: Tnfrsf1btm1.2Gkl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:264147
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was flanked by loxP sites and a FRT-flanked neo cassette was inserted upstream of the first loxP site via homologous recombination. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2, resulting in a frame shift mutation. (J:264147)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1b Mutation:  41 strains or lines available
References
Original:  J:264147 Sakkou M, et al., Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis. JCI Insight. 2018 Apr 5;3(7)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory