Tnfrsf1btm1.2Gkl
Targeted Allele Detail
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Symbol: |
Tnfrsf1btm1.2Gkl |
Name: |
tumor necrosis factor receptor superfamily, member 1b; targeted mutation 1.2, George Kollias |
MGI ID: |
MGI:6195556 |
Synonyms: |
Tnfrsf1bD |
Gene: |
Tnfrsf1b Location: Chr4:144940033-144973440 bp, - strand Genetic Position: Chr4, 78.17 cM
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Alliance: |
Tnfrsf1btm1.2Gkl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:264147
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2 was flanked by loxP sites and a FRT-flanked neo cassette was inserted upstream of the first loxP site via homologous recombination. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2, resulting in a frame shift mutation.
(J:264147)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tnfrsf1b Mutation: |
41 strains or lines available
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Original: |
J:264147 Sakkou M, et al., Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis. JCI Insight. 2018 Apr 5;3(7) |
All: |
1 reference(s) |
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