Gli2^{tm1(cre/ERT2)Tipe}
Targeted Allele Detail

Summary

• Symbol: Gli2^{tm1(cre/ERT2)Tipe}
• Name: GLI-Kruppel family member GLI2; targeted mutation 1, Tien Peng
• MGI ID: MGI:6195610
• Synonyms: Gli2^creERT2-tdT
• Gene: Gli2 Location: Chr1:118761862-118981349 bp, - strand Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
• Alliance: Gli2^{tm1(cre/ERT2)Tipe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264185
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Gli2^{tm1(cre/ERT2)Tipe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gli2 (MGI:95728)

• Mutation details: The allele was generated by inserting a CreERT2-2A-tdTomato expression cassette into the ATG site in exon2 of the Gli2 locus. (J:264185)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gli2 (mouse) Summary of all recombinase alleles driven by Gli2. Comparative matrix view of recombinase activities Alliance mouse Gli2 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli2 Mutation: 169 strains or lines available

References

• Original: J:264185 Wang C, et al., Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 Oct 1;128(10):4343-4358
• All: 1 reference(s)