Pold3^em1Linl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pold3^em1Linl
• Name: polymerase (DNA-directed), delta 3, accessory subunit; endonuclease-mediated mutation 1, Lin Liu
• MGI ID: MGI:6195840
• Gene: Pold3 Location: Chr7:99731317-99770709 bp, - strand Genetic Position: Chr7, 54.32 cM, cytoband F1
• Alliance: Pold3^em1Linl page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• An 11 bp frameshift deletion in exon 6 was introduced by CRISPR/Cas9 mutagenesis. (J:263620)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pold3 Mutation: 36 strains or lines available

References

• Original: J:263620 Zhou Z, et al., Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res. 2018 Apr 20;46(7):3468-3486
• All: 1 reference(s)