Prdm16^tm1.1Snok
Targeted Allele Detail

Summary

• Symbol: Prdm16^tm1.1Snok
• Name: PR domain containing 16; targeted mutation 1.1, Hans-Willem Snoeck
• MGI ID: MGI:6196056
• Synonyms: Prdm16^fl
• Gene: Prdm16 Location: Chr4:154400582-154721330 bp, - strand Genetic Position: Chr4, 83.96 cM, cytoband E2
• Alliance: Prdm16^tm1.1Snok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264335
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: THe targeting construct is designed to insert an FRT-flanked neomycin selection cassette, followed by a loxP site, upstream of exon 6, and a second loxP site downstream of exon 7 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 6 and 7 floxed. (J:264335)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prdm16 Mutation: 72 strains or lines available

References

• Original: J:264335 Corrigan DJ, et al., PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature. J Clin Invest. 2018 Aug 1;128(8):3250-3264
• All: 3 reference(s)