Dctn1^tm2.1Cai
Targeted Allele Detail

Summary

• Symbol: Dctn1^tm2.1Cai
• Name: dynactin 1; targeted mutation 2.1, Huaibin Cai
• MGI ID: MGI:6196333
• Synonyms: Dctn1^LoxP/
• Gene: Dctn1 Location: Chr6:83142902-83177099 bp, + strand Genetic Position: Chr6, 35.94 cM
• Alliance: Dctn1^tm2.1Cai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264431
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP-frt-neo-frt cassette upstream of exon 2, and a loxP site downstream of exon 4 of the dynactin 1 locus (Dctn1) on chromosome 6. Flp-mediated recombination removed the selection cassette. (J:264431)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dctn1 Mutation: 65 strains or lines available

References

• Original: J:264431 Yu J, et al., Genetic ablation of dynactin p150(Glued) in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice. Mol Neurodegener. 2018 Mar 1;13(1):10
• All: 2 reference(s)