Gsdme^em1Fsha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdme^em1Fsha
• Name: gasdermin E; endonuclease-mediated mutation 1, Feng Shao
• MGI ID: MGI:6196337
• Gene: Gsdme Location: Chr6:50167013-50240837 bp, - strand Genetic Position: Chr6, 24.13 cM
• Alliance: Gsdme^em1Fsha page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cas9 mRNA and two gRNAs (5'-GGGTTTCCCAAGAGGCTAGT-3' and 5'-GTGTGATATGGAGTACCCCG-3') were co-injected into C57BL/6NCrl zygotes, resulting in a 1417 bp deletion incorporating all of exon 3 of the mouse Gsdme gene. (J:250434)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gsdme Mutation: 42 strains or lines available

References

• Original: J:250434 Wang Y, et al., Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017 Jul 6;547(7661):99-103
• All: 16 reference(s)