Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Russell E Vance |
MGI ID: |
MGI:6196853 |
Synonyms: |
iOvaFla |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce page
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Germline Transmission: |
Earliest citation of germline transmission:
J:260047
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Mutation details: A construct encoding a loxP-flanked transcriptional STOP cassette upstream of chicken ovalbumin lacking its signal sequence fused to the C-terminal 166 amino acids of Legionella pneumophila flagellin and an IRES-GFP downstream of the fusion gene was targeted to the locus. This creates a conditional-ready allele that will only be expressed after cre-mediated deletion of the STOP cassette. Expression of flagellin activates endogenous NAIP/NLLRC4 inflammasome while the ovalbumin permits the tracking of the adaptive immune response.
(J:260047)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
993 strains or lines available
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Original: |
J:260047 Nichols RD, et al., NAIP/NLRC4 inflammasome activation in MRP8(+) cells is sufficient to cause systemic inflammatory disease. Nat Commun. 2017 Dec 20;8(1):2209 |
All: |
2 reference(s) |
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