Dusp14^em1Lyg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dusp14^em1Lyg
• Name: dual specificity phosphatase 14; endonuclease-mediated mutation 1, Yi-Gang Li
• MGI ID: MGI:6196886
• Synonyms: #20-2(alle2)
• Gene: Dusp14 Location: Chr11:83938859-83960016 bp, - strand Genetic Position: Chr11, 51.29 cM
• Alliance: Dusp14^em1Lyg page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 4 produced 6 different alleles: a 12 bp deletion (#20-1(alle1)), a 78 bp deletion (#20-1(alle2)), a 7 bp deletion (#20-2(alle1)), a 56 bp deletion (#20-2(alle2)), a 12 bp deletion (#32-1) and a 3 bp deletion (#32-3). Line #20-2(alle2) with a 56 bp deletion was used as the representative line. (J:263251)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp14 Mutation: 33 strains or lines available

References

• Original: J:263251 Li CY, et al., Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway. Basic Res Cardiol. 2016 Mar;111(2):19
• All: 2 reference(s)